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1,4-Dioxane (CAS: 123-91-1)
Common Names: Dioxane, 1,4-dioxacyclohexane, diethylene dioxide
A polar aprotic cyclic diether with active solvency 1,4-Dioxane is a highly polar aprotic (no hydroxyl functionality) solvent. It is a relatively inert solvent with outstanding stability at high pH. The moderate boiling point allows for easy separation and recovery from reaction mixtures. An excellent solvent for organometallic reagents.
Novolyte offers the highest purity (99.95%) and low moisture (100ppm max).
Physical Properties
| Empirical Formula |
C4H8O2 |
| Molecular Weight |
88.1 |
| Boiling Point (°C 760 mm Hg) |
100-102.5 |
| Freezing Point (°C) |
11 |
| Specific Gravity (20°C) |
1.0329 |
| Vapor Pressure (mm Hg/20°C) |
30 |
| Volatility (n-butylacetate = 100) |
270 |
| Viscosity (cp 20°C) |
1.2 |
| Surface Tension (dynes/cm 20°C) |
36.9 |
Explosive limits (Lower limit, v/v)
(Upper limit, v/v) |
2%
22% |
| Auto Ignition temp (°C) |
180 |
| Heat of Vaporization (cal/gram) |
98.6 |
| Heat of Combustion (K Cal/mole) |
581 |
| Henry's Law Constant (atm m3/mol) |
2.8 x10-6 |
| Flash Point (°C, closed cup) |
5-11 |
| Refractive Index (20°C) |
1.4224 |
Appearance: Clear, Colorless
Odor: Ethereal
Solubility at 25°C
- In water: complete
- Water in: complete
Process solvent
- For etching of Teflon and fluoropolymers with alkali metal dispersions
- Solvent vehicle for intermediate and pharmaceutical syntheses
- Electrolyte solutions for lithium batteries
Reaction solvent
- For the manufacture of drugs and API's
- For organomethallic reactions, including Grignard reactions
- For the manufacture of protease inhibitors (anti-AIDS drugs)
- Acting as a polycarbonate swelling agent
- Activator for metal borohydrides
Features
- Aprotic
- Moderate boiling point
- Water soluble
- High solvency characteristics
- Powerful diluent
- Excellent thermal and chemical stability
- Refer to MSDS for detailed handling and disposal information
- Use with proper PPE and engineering controls in enclosed applications