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Tetraethylene Glycol Dimethyl Ether CH3-O-(CH2CH2-O)4-CH3 (CAS: 143-24-8)
A polar aprotic glycol diether with active solvency and formulating versatility Tetraglyme is unique among ethylene oxide based solvents in that it is aprotic (no hydroxyl functionality). As a result it is a relatively inert solvent with outstanding chemical and thermal stability. Tetraglyme acts as a chelate ligand for cations. The high boiling point allows for easy separation of products from reaction mixtures and provides the ability to conduct reactions at high temperature. Tetraglyme is an excellent solvent for reactions involving NaBH4. Used as a solvent for Organometallic reactions involving reductions, alkylations and in reactions involving alkali metals.
Physical Properties
| Empirical Formula |
C10H22O5 |
| Molecular Weight |
222.28 |
| Boiling Point (°C 760 mm Hg) |
275 |
| Freezing Point (°C) |
-29.7 |
| Specific Gravity (20/20°C) |
1.0132 |
| Vapor Pressure (mm Hg/ 20°C) |
< 0.01 |
| Volatility (n-butylacetate = 100) |
< 0.1 |
| Viscosity (cp 20°C) |
4.1 |
| Surface Tension (dynes/cm 20°C) |
33.8 |
| Specific Heat (cal/gm/°C) |
0.427 |
| Auto Ignition temp (°C) |
215 |
| Heat of Vaporization (K cal/mole) |
18.7 |
| Heat of Combustion (K Cal/mole) |
1480 |
| Heat of Formation (K cal/mole) |
217 |
| Flash Point (°C, closed cup) |
141 |
| Refractive Index (20°C) |
1.4330 |
Appearance: Clear, Colorless
Odor: Mild, non-residual
Solubility at 25°C
- In water: complete
- Water in: complete
Process solvent
- As a HFC/CFC lubricant for refrigeration
- As a component of paint/graffiti remover formulations
- For dye fixation
- For solubilization for plastic, textile and printing inks
- For removal of H2S, CO and other acid gas components
- For absorption of halogenated liquids and gases
- For manufacture of solder pastes
Reaction solvent
- For manufacture of insecticides
- For anionic polymerizations
- For enhancing rates of nucleophilic substitution
- For sodium borohydride catalyzed reductions
Features
- Aprotic
- High boiling point
- Water soluble
- High solvency characteristics
- Powerful diluent & cleaner
- Excellent thermal and chemical stability
- Enhances yield and selectivity for NaBH4 reductions