Download this data sheet
Triglyme (CAS: 112-49-2)
Triethylene glycol dimethyl Ether CH3O(CH2CH2O)3CH3
An aprotic glycol diether with active solvency and formulating versatility Triglyme is unique among ethylene oxide based solvents in that it is aprotic (no hydroxyl functionality). As a result it is a relatively inert solvent with outstanding stability at high pH. The low boiling point allows for easy separation from reaction mixtures and recovery. Used as a solvent for Organometallic reactions involving reductions, alkylations, Grignard and in reactions involving alkali metals.
Physical Properties
| Empirical Formula |
C8H18O4 |
| Molecular Weight |
178.22 |
| Boiling Point (°C 760 mm Hg) |
216 |
| Freezing Point (°C) |
-45 |
| Specific Gravity (20°C) |
0.9862 |
| Vapor Pressure (mm Hg/20°C) |
0.02 |
| Volatility (n-butylacetate = 100) |
< 0.1 |
| Viscosity (cp 20°C) |
3.8 |
| Surface Tension (dynes/cm 20°C) |
29.4 |
| Auto Ignition temp (°C) |
195 |
| Heat of Vaporization (K Cal/mole) |
14.3 |
| Heat of Combustion (K Cal/mole) |
1191 |
| Flash Point (°C, closed cup) |
111 |
| Refractive Index (20°C) |
1.4224 |
Appearance: Clear
Odor: Ethereal
Solubility at 25°C
- In water: Complete
- Water in: Complete
Reaction solvent for:
- Organometallics for API synthesis
- Grignard reagents
- Synthesis and reaction of organolithium reagents
- The manufacture of protease inhibitors (anti-AIDS)
- Activator for metal borohydrides - often can use NaBH4 at higher temperatures in place of LiAlH4
- Solvent for Simmons-Smith reaction (addition of carbene to double bond)
Features
- Aprotic
- High boiling point
- Water soluble
- High solvency characteristics
- Excellent thermal and chemical stability
- Refer to MSDS for detailed handling and disposal information
- Use with proper PPE and engineering controls